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Recapturing the good times between you and your senior dog is now an exciting possibility, thanks to Anipryl® (selegiline hydrochloride, L-deprenyl hydrochloride) Tablets, the first and only drug approved by the FDA for the control of clinical signs associated with canine Cognitive Dysfunction Syndrome. Anipryl can be prescribed by your veterinarian after a diagnosis of CDS has been determined.
Anipryl comes in a convenient tablet form for easy dosing. Most dogs are prescribed one tablet each day, preferably in the morning. (Anipryl can be given with food.) It's important to administer every tablet as directed, since interruption of therapy could lead to the reappearance of signs.
In studies, pet owners reported that 69% to 75% of dogs improved in at least one clinical sign after one month of Anipryl therapy. Because CDS is a syndrome (a collection of signs), no two dogs will show exactly the same signs. Response to Anipryl may vary from dog to dog.
In the blinded, placebo-controlled study, owners reported that 69% of dogs improved in at least one clinical sign after one month of Anipryl therapy, compared to 52% of placebo-treated dogs. A second open label clinical study revealed that 75% of dogs improved in at least one clinical sign after one month of Anipryl therapy. Some dogs in both studies showed increased improvement during the three-month studies, indicating that some increased improvement may be seen with continued use. However, onset, duration and magnitude of response varied with individual dogs.
In studies, the most common side effects were vomiting, diarrhea or changes in behavior, such as hyperactivity and restlessness. Most side effects were mild to moderate. In the placebo-controlled study, most of the adverse events in dogs treated with Anipryl were also observed in placebo-treated dogs, although the rates in these dogs were lower. Consult your veterinarian before using Anipryl with other medications or with tick collars. As dogs grow older, they are likely to experience more health problems. Senior dogs should be
observed more closely, because changes in normal appearance, activity and behavior all can be signs that veterinary attention may be needed. Always contact your veterinarian if you notice anything unusual in your dog's appearance or behavior.
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